Conference Day Two
8:15 am Login & Networking
Synopsis
Join our morning virtual coffee chat room to meet with your fellows and get the conversation going!8:30 am Opening Remarks from the Chair
Computational Drug Development for Biologics 2.0
9:00 am Leveraging Bioinformatics to Support Drug Development
Synopsis
- Bioinformatics tools to help us profile and understand the effect of multi-mutations in recombinant protein sequencing
- Codon usage tables of all species, human tissues and cancer primary cells to assist with various techniques, such as gene therapy or cancer vaccines
- Examples for future considerations
9:10 am Session Reserved for Schrodinger, Inc
9:40 am A Cross-Product Method for Rapidly De-Risking Chemical Liabilities in Antibody Based Candidates
Synopsis
- Exploring rationale and initial successes
- Delving into lessons learned and hurdles to initial implementation, such as data format and quality
10:10 am Panel Discussion: Exploring Data Availability & Accessibility Opportunities & Challenges
Synopsis
- Determining the need to build more data and how to focus these collaborations internally and externally
- Discovering methods to utilize limited data to accelerate your drug discovery and development
10:45 am Morning Speed Networking
Synopsis
Connect with your industry peers through our virtual speed networking tool. You will be paired up with a fellow colleague for a 5-minute ice breaking conversation!
11:15 am Ensembles in Solution as a New Paradigm in Antibody Structure Design
Synopsis
- Exploring paratope states in solution
- Determining antibody-antigen recognition – docking
11:45 am Utilizing Molecular Modeling to Guide Biotherapeutics Formulation
Synopsis
- Intravenous vs. subcutaneous: Story of the first oncology mAb and need for high concentration formulation
- Where and how in silico modeling can help biotherapeutics formulation? Risk assessment; protein-protein interactions; virtual excipient screening
- Opportunities and future directions to expand the usage of modeling in biologics drug product development
12:15 pm Panel Discussion: Analyzing Computational Design & Characterization of Nanobodies
Synopsis
- Reviewing currently emerging and powerful nanobodies approved in market
- Exploring better, logistic alternatives to intravenously administered antibodies
12:45 pm Lunch
Synopsis
Grab a bite while joining our virtual lunch chat room, or use this opportunity to visit our Partners’ Virtual Booths
De Novo Antibody Design through Computational Tools
1:30 pm Antibody Modeling: Is High-Accuracy Required to Enable Design & Engineering?
Synopsis
- Strengths and weaknesses of antibody design & optimization
- Utilizing comparative modelling to bridge the gap between sequence and structure space
- Overview of available databases, methods and emerging trends in antibody analysis and engineering of optimized antibody therapeutics
2:00 pm A Novel & Efficient Workflow for the Humanization of Therapeutic Monoclonal Antibodies
Synopsis
- Obstacles to selecting the optimal template for humanization
- The Structural Annotation Index (SAI) as an indicator to guide selection of back mutations
- Optimal pairing of VH/VL chains
2:30 pm Afternoon Speed Networking
Synopsis
Take this opportunity to meet with our expert partners for 1-2-1 meetings to find out about their latest innovations.
3:00 pm Improving the Drug-Like Properties of Affinity-Matured Antibodies via QSPR
Synopsis
- Affinity maturation often produces a panel of prospective lead candidates
- These candidates have a diverse range of drug-like properties
- Utilizing QSPR and machine Learning we are able to identify residues that drive an unwanted drug-like property
- In this talk, we validate this approach by mitigating off-target interactions of high-affinity binders
3:30 pm Timescales & Mechanisms of Amyloid Aggregation
Synopsis
- Appreciating amyloid aggregation spans timescales from nanoseconds to decades
- Theory mechanisms and timescales associated with secondary structure formation, template search, and nucleation
- Using insights from theory, multi-scale simulations are used to target events at each timescale
4:00 pm Strategies to Enhance NK Cell Therapies Using Single Cell Multi-Omics Approaches
Synopsis
This session will focus on how advanced single cell multi-omics technologies and translational informatics will play a critical role in cell therapy drug development.