13-15 November 2018

Woburn, Boston, MA

Workshop A
Tuesday 13 November 2018

09.00 - 12.00
Beyond Antibodies: Biologic Drug Development With Genetically-Encodable Constrained Peptides

Antibodies make great drugs, but they’re not a one-size-fits-all solution. Genetically-encodable constrained peptides are an alternative scaffold that can be useful for applications where antibodies are not ideal, e.g. gastrointestinal, pulmonary, topical.

This session will explore:

  • For which diseases are constrained peptides suitable as therapeutics, and what are the advantages over small molecules and antibodies?
  • Interfacing genetically-encodable peptides with synthetic biology: what are the opportunities and roadblocks?
  • What are the challenges of a computational approach to the design of constrained peptides, and how can these be overcome?

Workshop Leader:

Christopher D. Bahl
Head of Protein Design,
Institute for Protein Innovation

Workshop B
Tuesday 13 November 2018

13.00 - 16.00
Using Computational Tools To Design & Optimize Novel Biologics

Engage directly with protein and cell engineers to address how to create novel therapeutics that go beyond monoclonal antibodies and naturally occurring proteins.

Attendees will discuss:

  • How to define product profiles that can be achieved by rational design
  • How to design useful starting entities
  • Tissue targeting of therapeutic cells and proteins to minimize side effects
    Optimizing pharmacokinetics

Workshop Leader:

Jeffrey Way
Senior Staff Scientist
Wyss Institute, Harvard University