Affinity-Aware In Silico Humanization Using a Domain-Specific Deep Learning Affinity Oracle
Time: 4:30 pm
day: Day One
Details:
- Developed and validated an affinity oracle for antibody-antigen binding by integrating context-specific protein-protein interaction (PPI) data with ESM-2 and transfer learning techniques
- Leveraged the affinity oracle to assess mutations that revert antibodies to their germline state for the purpose of humanization
- Conducted experimental validation of model predictions through biophysical characterization
