Physics-Based Simulations to Investigate Developability for Therapeutic Antibodies

Time: 12:30 pm
day: Day One


  • The development of in silico models for stability prediction proves challenging due to the limited availability of adequately sized experimental data necessary for model training
  • The emergence of novel therapeutic modalities can further restrict the sizes of datasets, and thus the transferability and generalizability of predictive methods
  • Physics-based approaches that are not limited on training data offer a unique advantage by providing profound mechanistic insight into the physical and chemical stability, examples of such class of computations will be presented