Exploring a Theoretical Framework to Guide De Novo Biologic Design

Time: 3:00 pm
day: Day One


  • Task 1: Given the antigen sequence, can you set the sequence motif of the antibody to make a reliable prediction on whether a particular antibody would bind to this antigen?
  • Task 2: Given an antibody sequence, can you identify the most likely epitope on a particular antigen if you already know that this antibody binds to this antigen?
  •  Task 3: Given a known antibody sequence that binds to a particular epitope on an antigen, how many different antibody sequences we identify that will bind to the same epitope?
  • Task 4: Given an arbitrary antigen, can we identify one or a few epitopes that can help design an antibody sequence binding to the designated epitope?