13-15 November 2018

Woburn, Boston, MA

Day One
Wednesday 14th November 2018

Day Two
Thursday 15th November 2018

07.30
Registration & Refreshments

08.20
Chair’s Opening Remarks

  • Vanita Sood Global Head of Drug Structure, Prediction & Design, EMD Serono

08.30
From Conformation to Population & Back Again

Computational Tools for Accelerating Antibody & Target Selection

09.00
Applications of Current Computational Tools for Antibody Development

  • Bojana Popovic Principal Scientist - Antibody Discovery and Protein Engineering, MedImmune Protein Engineering, , MedImmune

09.30
Computational Approaches for Optimizing the Developability of Biotherapeutics

  • John Gunn Senior Research Scientist, Chemical Computing Group

10.00
Speed Networking

10.30
Morning Refreshment Break

Predicting Protein Liabilities and Improving of Developability

11.00
BioQSPR: A Computational Framework to Address Liabilities in Biotherapeutics

11.30
Deep Sequencing Combined with In-Silico Modelling to Advance Biotherapeutic Discovery

12.00
The Role of Structural Analysis in the Improvement of AI Methods Used in Drug Design

12.30
Lunch & Networking

13.30
Integrating Structural Data with the Human Interactome to Support Target Discovery & Characterization

14.00
Designing Aggregation Resistance by Mapping Key Inter-Protein Amino Acid Pairings

  • Chris Roberts Professor of Chemical and Biomolecular Engineering, University of Delaware

14.00
Molecular Dynamics for Antibody Developability Prediction

14.30
Developability Risk Assessment for Novel Biologics Selection in Lead Generation Process

15.00
Afternoon Refreshments & Networking

Computer-Aided Prediction of Structure and Design of Function

16.00
Antibody Structure Prediction, Docking & Design

  • Jeffrey Grey Professor Chemical & Biomolecular Engineering, Johns Hopkins University School of Medicine

16.30
ADAPTing CDR H3: Re-engineering H3 Loops Using a Germline Sequence Library

  • Enrico O. Purisima Molecular Modeling Team Leader, National Research Council Canada, Human Health Therapeutics Research Centre

17.00
RosettaAntibodyDesign (RAbD): A General Framework for Computational Antibody Design

17.30
End of Conference Day One

Evening Reception & Poster Session Kindly Hosted by Schrodinger

Synopsis